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KMID : 0606319990160010033
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Journal of Phamacetical Sciences Sookmyung Women s University
1999 Volume.16 No. 1 p.33 ~ p.49
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Synthesis, Anticancer Activity and Cellcycle Specificity of Water-Soluble PT(II) Complexes Containing Riboflavin
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Whang Kyu-Ja
Kwon Young-Ee
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Abstract
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A series of vitamine-containing PT(II) complexes of the type [Pt(Rf)(L)I, (where Rf=riboflavin, L=ethylenediamine, 1,3-propanediamine, 1,4-butanediamine) was synthesized and characterized by IR, electronic absorption, elemental analysis and FAB-Mass. The coordination sites of Rf to PT(II) ions were determined to be N(5) and 0(6) with resultant chelate ring formation. These compouds have much better water solubility (145-150mg/ml) than cisplatin has (1mg/ml). The anticancer activity of this Riboflavin-containing PT(II) series was investigated by MTT assay against mouse and human leukemia cell lines in vitro. Interaction between PT(II) complex and DNA were analyzed by flowcytometry, and showed G2/M arrest in L1210 cell line.
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